Drug Name Generic name: propofol injectable emulsion Used name propofol injection
Brand name: Di shi ning English name: propofol injectable emulsion
Chinese spell: Bingbofen Ruzhuangzhusheye
Ingredients Chemical name: 2,6-Dissoprophylphenol Chemical structure: OH CH3 CH3 H3C H3C Molecular formula: C12H18O Molecular weight: 178.27
Excipients: soybean oil, glycerin, egg yolk lecithin, sodium hydroxide, water for injection
Description: The product is a white, uniform, and lacteal liquid.Strength 50ml:1g
Dosage and Administration The product is only used in the hospital or outpatient treatment room with well-found equipment, and must be used by the doctors trained in anesthesia and intensive care. Continually monitor the breath and circulatory function (e.g. electrocardiogram, oxyhemoglobin saturation) of patients, and facilities for maintenance of a patent airway, providing artificial ventilation and other instituting resuscitation must be immediately available. The product should not be administered by person involved in the conduct of the surgical/diagnostic procedure during the sedation of surgery and diagnostic procedure. According to patient responses and premedication, the administration should be individualized. In general, the product anesthesia is supplemented with analgesic agents.
Anesthesia maintenance Maintain the depth of anesthesia by continual intravenous infusion or repetitive injection of the product. The routine dosage to maintain anesthesia is 4~12 mg/kg per hour calculated by body weight. The maintenance dosage reduces to 4mg/kg per hour calculated by body weight during the minor operation of stress, e.g. minimally invasive surgery. For old people, patients with unstable situation, cardiopulmonary insufficiency, hypovolemia or ASA III-IV, further reduce the dosage of product according to the gravity of patients' illness and the anesthesia technology adopted. The general anesthesia of children over three years Anesthesia induction The product is slowly instilled to conduct anesthesia induction until the clinical signs show the onset of anesthesia. The dosage should be adjusted according to age or body weight. For most of children over 8 years of age, the routine dosage is 2.5mg/kg calculated by body weight while conducting anesthesia induction with the product. For children under 8 years of age, especially children from 1 month through 3 years of age, the required dosage may be higher. (2.5~4mg/kg calculated by body weight) General Anesthesia maintenance Maintain the required level of anesthesia by continual intravenous infusion. There is apparent difference in administration rate of different patients, generally achieve the satisfactory effect of anesthesia maintenance under the administration rate of 9~15mg/kg per hour calculated by body weight. For younger children, the required dosage may be higher. For ASA III-IV patients, it is recommended to use the lower dosage (see ATTENTIONS) The sedation at the time of the surgery and diagnosis of adults.
Pregnant and nursing women use Although animal studies indicate the product has no the teratogenic effect, the product should not be used in pregnancy. The propofol may cause the newborn inhibition by placental barrier. It is not recommended to use the product in the aspect of obstertrics anesthesia, including abdominal delivery. The studies of lactation women indicate a small amount of propofol can be excreted in human milk. The nursing women should stop the lactation within 24hrs after using the product. The pregnancy women and obstetric patients must not use the product (excluding abortion patients)
Storage: Preserve in a tightly container at 2~25ºC, do not freeze.
Package: vials, 10 PCS/box or 60vials/carton
Expiry date: 24 months
Manufacturer Manufacturer name: Guangdong Jiabo Pharmaceutical Co., Ltd.
Manufacturing address: Bio-Pharmaceutical Park, High &New Technology industries development Zone, Qingyuan City, Guangdong Province